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Hashim, S. R.
- 'Transport Coefficients' and Transport Input-Vector (Goods Transportation-Railways)
Authors
Source
Artha Vijnana: Journal of The Gokhale Institute of Politics and Economics, Vol 11, No 2 (1969), Pagination: 224-235Abstract
In the scheme of inter-sectoral balance of economic activities (the inter-industry flow matrix), inter-spatial balance is assumed to be achieved by taking transport as one of the sectors and expressing the demand for it by other sectors as a flxed proportion of their outputs.- A Model for Optimum Location and Flows
Authors
Source
Artha Vijnana: Journal of The Gokhale Institute of Politics and Economics, Vol 11, No 2 (1969), Pagination: 288-302Abstract
With the growing realization of the concept and importance of space as an explicit factor in the process of economic change interest has grown in empirically highlighting the inter-spatial connections. Prof. Leontief observes: "The movement of commodities and services between separate geographic areas and the internal economic structure of such regions are mutually inter-dependent.- Synthesis and Anti-Inflammatory Activity of Novel 2-N-Alkyl Sulfonamide Substituted Derivatives of N-Phenyl Anthranilic Acid
Authors
1 College of Pharmacy, Institute of Foreign Trade Management, Moradabad, U.P., IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 4 (2011), Pagination: 656-660Abstract
Anthranilic acid class of NSAIDs is the result of the application of classical medicinal chemistry bioisosteric drug design concepts since these derivatives are Nitrogen isosteres of Salicylic acid. N-substituted anthranilic acids have found application in widely varying therapeutics areas including anti-inflammatory, analgesic, antipyretics, diuretics, antifibrinolytic, antimicrobial, anticancer activity. In view of these pharmacological observations of N-substituted anthranilic acid derivatives, it was thought worthwhile to synthesize some new N-substituted anthranilic acid derivatives by incorporating (substituted) benzyl and sulphonyl moieties, at the amino group of the anthranilic acid with the hope to get better anti-inflammatory and analgesic molecules.
Present research work deals with the substitution of N-alkyl sulfonamide group and iodine on 2nd and 7th positions of acridone nucleus respectively, to give improved antimicrobial activity. The Ullmann reaction is used for their synthesis, which is based on the reaction of o-halobenzoic acid with arylamines in n-aryl alcohol medium in the presence of potassium carbonate and copper powder. Ullmann reaction synthesizes substituted N-phenyl anthranilic acid. All the derivatives tested showed a moderate spectrum of anti-inflammatory. Thus it is possible that substitution at position 2 of the anthranilic acid by sulfonamidophenyl and modification on the sulfonamide moiety by using various amines and substituting iodine on 5th position may yield compounds of much improved activity.